Monoubiquitination and endocytosis direct γ-secretase cleavage of activated Notch receptor

Activation of mammalian Notch receptor by its ligands induces TNFα-converting enzyme–dependent ectodomain shedding, followed by intramembrane proteolysis due to presenilin (PS)-dependent γ-secretase activity. Here, we demonstrate that a new modification, a monoubiquitination, as well as clathrin-dep...

Descripción completa

Detalles Bibliográficos
Autores principales: Gupta-Rossi, Neetu, Six, Emmanuelle, LeBail, Odile, Logeat, Frédérique, Chastagner, Patricia, Olry, Annie, Israël, Alain, Brou, Christel
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2004
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2172142/
https://www.ncbi.nlm.nih.gov/pubmed/15240571
http://dx.doi.org/10.1083/jcb.200310098

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2172142/
https://www.ncbi.nlm.nih.gov/pubmed/15240571
http://dx.doi.org/10.1083/jcb.200310098

Ejemplares similares