Endorepellin causes endothelial cell disassembly of actin cytoskeleton and focal adhesions through α2β1 integrin

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Endorepellin, the COOH-terminal domain of the heparan sulfate proteoglycan perlecan, inhibits several aspects of angiogenesis. We provide evidence for a novel biological axis that links a soluble fragment of perlecan protein core to the major cell surface receptor for collagen I, α2β1 integrin, and...

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Detalles Bibliográficos
Autores principales: Bix, Gregory, Fu, Jian, Gonzalez, Eva M., Macro, Laura, Barker, Amy, Campbell, Shelly, Zutter, Mary M., Santoro, Samuel A., Kim, Jiyeun K., Höök, Magnus, Reed, Charles C., Iozzo, Renato V.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2004
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2172143/
https://www.ncbi.nlm.nih.gov/pubmed/15240572
http://dx.doi.org/10.1083/jcb.200401150
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