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Distinct roles for ADAM10 and ADAM17 in ectodomain shedding of six EGFR ligands

All ligands of the epidermal growth factor receptor (EGFR), which has important roles in development and disease, are released from the membrane by proteases. In several instances, ectodomain release is critical for activation of EGFR ligands, highlighting the importance of identifying EGFR ligand s...

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Detalles Bibliográficos
Autores principales:	Sahin, Umut, Weskamp, Gisela, Kelly, Kristine, Zhou, Hong-Ming, Higashiyama, Shigeki, Peschon, Jacques, Hartmann, Dieter, Saftig, Paul, Blobel, Carl P.
Formato:	Texto
Lenguaje:	English
Publicado:	The Rockefeller University Press 2004
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2172154/ https://www.ncbi.nlm.nih.gov/pubmed/14993236 http://dx.doi.org/10.1083/jcb.200307137

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