Regulation of Ras–MAPK pathway mitogenic activity by restricting nuclear entry of activated MAPK in endoderm differentiation of embryonic carcinoma and stem cells

In response to retinoic acid, embryonic stem and carcinoma cells undergo differentiation to embryonic primitive endoderm cells, accompanied by a reduction in cell proliferation. Differentiation does not reduce the activation of cellular MAPK/Erk, but does uncouple mitogen-activated protein kinase (M...

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Detalles Bibliográficos
Autores principales: Smith, Elizabeth R., Smedberg, Jennifer L., Rula, Malgorzata E., Xu, Xiang-Xi
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2004
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2172165/
https://www.ncbi.nlm.nih.gov/pubmed/14981092
http://dx.doi.org/10.1083/jcb.200312028

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2172165/
https://www.ncbi.nlm.nih.gov/pubmed/14981092
http://dx.doi.org/10.1083/jcb.200312028

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