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Degradative organelles containing mislocalized α- and β-synuclein proliferate in presenilin-1 null neurons
Presenilin-1 null mutation (PS1 −/−) in mice is associated with morphological alterations and defects in cleavage of transmembrane proteins. Here, we demonstrate that PS1 deficiency also leads to the formation of degradative vacuoles and to the aberrant translocation of presynaptic α- and β-synuclei...
| Autores principales: | , , , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
The Rockefeller University Press
2004
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2172178/ https://www.ncbi.nlm.nih.gov/pubmed/15123735 http://dx.doi.org/10.1083/jcb.200403061 |