Signaling switches and bistability arising from multisite phosphorylation in protein kinase cascades

Mitogen-activated protein kinase (MAPK) cascades can operate as bistable switches residing in either of two different stable states. MAPK cascades are often embedded in positive feedback loops, which are considered to be a prerequisite for bistable behavior. Here we demonstrate that in the absence o...

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Detalles Bibliográficos
Autores principales: Markevich, Nick I., Hoek, Jan B., Kholodenko, Boris N.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2004
Materias:
Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2172246/
https://www.ncbi.nlm.nih.gov/pubmed/14744999
http://dx.doi.org/10.1083/jcb.200308060

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2172246/
https://www.ncbi.nlm.nih.gov/pubmed/14744999
http://dx.doi.org/10.1083/jcb.200308060

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