Protein kinase Cι is required for Ras transformation and colon carcinogenesis in vivo

Protein kinase C ι (PKCι) has been implicated in Ras signaling, however, a role for PKCι in oncogenic Ras-mediated transformation has not been established. Here, we show that PKCι is a critical downstream effector of oncogenic Ras in the colonic epithelium. Transgenic mice expressing constitutively...

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Detalles Bibliográficos
Autores principales: Murray, Nicole R., Jamieson, Lee, Yu, Wangsheng, Zhang, Jie, Gökmen-Polar, Yesim, Sier, Deborah, Anastasiadis, Panos, Gatalica, Zoran, Thompson, E. Aubrey, Fields, Alan P.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2004
Materias:
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2172278/
https://www.ncbi.nlm.nih.gov/pubmed/15024028
http://dx.doi.org/10.1083/jcb.200311011

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