FAK and paxillin: regulators of N-cadherin adhesion and inhibitors of cell migration?

FAK and paxillin are important components in integrin-regulated signaling. New evidence suggests that these two proteins function in crosstalk between cell–matrix and cell–cell adhesions. Further, new insight suggests that under some conditions these proteins inhibit cell migration, in contrast to t...

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Detalles Bibliográficos
Autor principal: Schaller, Michael D.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2004
Materias:
Reviews
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2172300/
https://www.ncbi.nlm.nih.gov/pubmed/15263014
http://dx.doi.org/10.1083/jcb.200406151
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author Schaller, Michael D.
author_facet Schaller, Michael D.
author_sort Schaller, Michael D.
collection PubMed
description FAK and paxillin are important components in integrin-regulated signaling. New evidence suggests that these two proteins function in crosstalk between cell–matrix and cell–cell adhesions. Further, new insight suggests that under some conditions these proteins inhibit cell migration, in contrast to their established roles in several cell systems as positive regulators of cell adhesion and migration.
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spelling pubmed-21723002008-03-05 FAK and paxillin: regulators of N-cadherin adhesion and inhibitors of cell migration? Schaller, Michael D. J Cell Biol Reviews FAK and paxillin are important components in integrin-regulated signaling. New evidence suggests that these two proteins function in crosstalk between cell–matrix and cell–cell adhesions. Further, new insight suggests that under some conditions these proteins inhibit cell migration, in contrast to their established roles in several cell systems as positive regulators of cell adhesion and migration. The Rockefeller University Press 2004-07-19 /pmc/articles/PMC2172300/ /pubmed/15263014 http://dx.doi.org/10.1083/jcb.200406151 Text en Copyright © 2004, The Rockefeller University Press This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Reviews
Schaller, Michael D.
FAK and paxillin: regulators of N-cadherin adhesion and inhibitors of cell migration?
title FAK and paxillin: regulators of N-cadherin adhesion and inhibitors of cell migration?
title_full FAK and paxillin: regulators of N-cadherin adhesion and inhibitors of cell migration?
title_fullStr FAK and paxillin: regulators of N-cadherin adhesion and inhibitors of cell migration?
title_full_unstemmed FAK and paxillin: regulators of N-cadherin adhesion and inhibitors of cell migration?
title_short FAK and paxillin: regulators of N-cadherin adhesion and inhibitors of cell migration?
title_sort fak and paxillin: regulators of n-cadherin adhesion and inhibitors of cell migration?
topic Reviews
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2172300/
https://www.ncbi.nlm.nih.gov/pubmed/15263014
http://dx.doi.org/10.1083/jcb.200406151
work_keys_str_mv AT schallermichaeld fakandpaxillinregulatorsofncadherinadhesionandinhibitorsofcellmigration

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