Triggering p53 after cytokinesis failure

Cells that fail to divide during cytokinesis often arrest in the next G1 phase by a mysterious mechanism that depends upon p53. What triggers this arrest is unclear. New studies, including a report in this issue (Uetake and Sluder, 2004) suggest that this arrest does not occur because cells are poly...

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Detalles Bibliográficos
Autor principal: Stukenberg, P. Todd
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2004
Materias:
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2172375/
https://www.ncbi.nlm.nih.gov/pubmed/15184396
http://dx.doi.org/10.1083/jcb.200405089
Descripción
Sumario:Cells that fail to divide during cytokinesis often arrest in the next G1 phase by a mysterious mechanism that depends upon p53. What triggers this arrest is unclear. New studies, including a report in this issue (Uetake and Sluder, 2004) suggest that this arrest does not occur because cells are polyploid, are binucleate, have multiple centrosome, or have failed cytokinesis, making this phenomenon even more puzzling.

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