Triggering p53 after cytokinesis failure

Cells that fail to divide during cytokinesis often arrest in the next G1 phase by a mysterious mechanism that depends upon p53. What triggers this arrest is unclear. New studies, including a report in this issue (Uetake and Sluder, 2004) suggest that this arrest does not occur because cells are poly...

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Detalles Bibliográficos
Autor principal: Stukenberg, P. Todd
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2004
Materias:
Comment
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2172375/
https://www.ncbi.nlm.nih.gov/pubmed/15184396
http://dx.doi.org/10.1083/jcb.200405089
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author Stukenberg, P. Todd
author_facet Stukenberg, P. Todd
author_sort Stukenberg, P. Todd
collection PubMed
description Cells that fail to divide during cytokinesis often arrest in the next G1 phase by a mysterious mechanism that depends upon p53. What triggers this arrest is unclear. New studies, including a report in this issue (Uetake and Sluder, 2004) suggest that this arrest does not occur because cells are polyploid, are binucleate, have multiple centrosome, or have failed cytokinesis, making this phenomenon even more puzzling.
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spelling pubmed-21723752008-03-05 Triggering p53 after cytokinesis failure Stukenberg, P. Todd J Cell Biol Comment Cells that fail to divide during cytokinesis often arrest in the next G1 phase by a mysterious mechanism that depends upon p53. What triggers this arrest is unclear. New studies, including a report in this issue (Uetake and Sluder, 2004) suggest that this arrest does not occur because cells are polyploid, are binucleate, have multiple centrosome, or have failed cytokinesis, making this phenomenon even more puzzling. The Rockefeller University Press 2004-06-07 /pmc/articles/PMC2172375/ /pubmed/15184396 http://dx.doi.org/10.1083/jcb.200405089 Text en Copyright © 2004, The Rockefeller University Press This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Comment
Stukenberg, P. Todd
Triggering p53 after cytokinesis failure
title Triggering p53 after cytokinesis failure
title_full Triggering p53 after cytokinesis failure
title_fullStr Triggering p53 after cytokinesis failure
title_full_unstemmed Triggering p53 after cytokinesis failure
title_short Triggering p53 after cytokinesis failure
title_sort triggering p53 after cytokinesis failure
topic Comment
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2172375/
https://www.ncbi.nlm.nih.gov/pubmed/15184396
http://dx.doi.org/10.1083/jcb.200405089
work_keys_str_mv AT stukenbergptodd triggeringp53aftercytokinesisfailure

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