Cellular stresses induce the nuclear accumulation of importin α and cause a conventional nuclear import block

We report here that importin α accumulates reversibly in the nucleus in response to cellular stresses including UV irradiation, oxidative stress, and heat shock. The nuclear accumulation of importin α appears to be triggered by a collapse in the Ran gradient, resulting in the suppression of the nucl...

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Detalles Bibliográficos
Autores principales: Miyamoto, Yoichi, Saiwaki, Takuya, Yamashita, Junichi, Yasuda, Yoshinari, Kotera, Ippei, Shibata, Satoshi, Shigeta, Masaki, Hiraoka, Yasushi, Haraguchi, Tokuko, Yoneda, Yoshihiro
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2004
Materias:
Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2172376/
https://www.ncbi.nlm.nih.gov/pubmed/15184398
http://dx.doi.org/10.1083/jcb.200312008

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