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Absence of BLM leads to accumulation of chromosomal DNA breaks during both unperturbed and disrupted S phases
Bloom's syndrome (BS), a disorder associated with genomic instability and cancer predisposition, results from defects in the Bloom's helicase (BLM) protein. In BS cells, chromosomal abnormalities such as sister chromatid exchanges occur at highly elevated rates. Using Xenopus egg extracts,...
| Autores principales: | , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
The Rockefeller University Press
2004
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2172405/ https://www.ncbi.nlm.nih.gov/pubmed/15197177 http://dx.doi.org/10.1083/jcb.200402095 |