Membrane insertion of anthrax protective antigen and cytoplasmic delivery of lethal factor occur at different stages of the endocytic pathway

The protective antigen (PA) of anthrax toxin binds to a cell surface receptor, undergoes heptamerization, and binds the enzymatic subunits, the lethal factor (LF) and the edema factor (EF). The resulting complex is then endocytosed. Via mechanisms that depend on the vacuolar ATPase and require membr...

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Detalles Bibliográficos
Autores principales: Abrami, Laurence, Lindsay, Margaret, Parton, Robert G., Leppla, Stephen H., van der Goot, F. Gisou
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2004
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2172425/
https://www.ncbi.nlm.nih.gov/pubmed/15337774
http://dx.doi.org/10.1083/jcb.200312072

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2172425/
https://www.ncbi.nlm.nih.gov/pubmed/15337774
http://dx.doi.org/10.1083/jcb.200312072

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