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Apoptotic pathways are selectively activated by granzyme A and/or granzyme B in CTL-mediated target cell lysis

Purified cytolytic T lymphocyte (CTL) proteases granzyme (gzm)A and gzmB with sublytic dose of perforin (perf) initiate distinct proapoptotic pathways. Their physiological relevance in CTL-mediated target cell apoptosis is elusive. Using ex vivo virus-immune CD8(+) T cells from mice deficient in per...

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Detalles Bibliográficos
Autores principales:	Pardo, Julián, Bosque, Alberto, Brehm, Reina, Wallich, Reinhard, Naval, Javier, Müllbacher, Arno, Anel, Alberto, Simon, Markus M.
Formato:	Texto
Lenguaje:	English
Publicado:	The Rockefeller University Press 2004
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2172484/ https://www.ncbi.nlm.nih.gov/pubmed/15534000 http://dx.doi.org/10.1083/jcb.200406115

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