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Disruption of LTBP-4 function reduces TGF-β activation and enhances BMP-4 signaling in the lung

Disruption of latent TGF-β binding protein (LTBP)–4 expression in the mouse leads to abnormal lung development and colorectal cancer. Lung fibroblasts from these mice produced decreased amounts of active TGF-β, whereas secretion of latent TGF-β was significantly increased. Expression and secretion o...

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Detalles Bibliográficos
Autores principales:	Koli, Katri, Wempe, Frank, Sterner-Kock, Anja, Kantola, Anna, Komor, Martina, Hofmann, Wolf-K., von Melchner, Harald, Keski-Oja, Jorma
Formato:	Texto
Lenguaje:	English
Publicado:	The Rockefeller University Press 2004
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2172518/ https://www.ncbi.nlm.nih.gov/pubmed/15466481 http://dx.doi.org/10.1083/jcb.200403067

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