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Rap1 promotes cell spreading by localizing Rac guanine nucleotide exchange factors

The Ras-related GTPase Rap1 stimulates integrin-mediated adhesion and spreading in various mammalian cell types. Here, we demonstrate that Rap1 regulates cell spreading by localizing guanine nucleotide exchange factors (GEFs) that act via the Rho family GTPase Rac1. Rap1a activates Rac1 and requires...

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Detalles Bibliográficos
Autores principales:	Arthur, William T., Quilliam, Lawrence A., Cooper, Jonathan A.
Formato:	Texto
Lenguaje:	English
Publicado:	The Rockefeller University Press 2004
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2172522/ https://www.ncbi.nlm.nih.gov/pubmed/15479739 http://dx.doi.org/10.1083/jcb.200404068

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