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Endothelial barrier disruption by VEGF-mediated Src activity potentiates tumor cell extravasation and metastasis

VEGF is unique among angiogenic growth factors because it disrupts endothelial barrier function. Therefore, we considered whether this property of VEGF might contribute to tumor cell extravasation and metastasis. To test this, mice lacking the Src family kinases Src or Yes, which maintain endothelia...

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Detalles Bibliográficos
Autores principales:	Weis, Sara, Cui, Jianhua, Barnes, Leo, Cheresh, David
Formato:	Texto
Lenguaje:	English
Publicado:	The Rockefeller University Press 2004
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2172541/ https://www.ncbi.nlm.nih.gov/pubmed/15504909 http://dx.doi.org/10.1083/jcb.200408130

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