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Condensin restructures chromosomes in preparation for meiotic divisions
The production of haploid gametes from diploid germ cells requires two rounds of meiotic chromosome segregation after one round of replication. Accurate meiotic chromosome segregation involves the remodeling of each pair of homologous chromosomes around the site of crossover into a highly condensed...
Autores principales: | , , |
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Formato: | Texto |
Lenguaje: | English |
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The Rockefeller University Press
2004
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2172564/ https://www.ncbi.nlm.nih.gov/pubmed/15557118 http://dx.doi.org/10.1083/jcb.200408061 |
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author | Chan, Raymond C. Severson, Aaron F. Meyer, Barbara J. |
author_facet | Chan, Raymond C. Severson, Aaron F. Meyer, Barbara J. |
author_sort | Chan, Raymond C. |
collection | PubMed |
description | The production of haploid gametes from diploid germ cells requires two rounds of meiotic chromosome segregation after one round of replication. Accurate meiotic chromosome segregation involves the remodeling of each pair of homologous chromosomes around the site of crossover into a highly condensed and ordered structure. We showed that condensin, the protein complex needed for mitotic chromosome compaction, restructures chromosomes during meiosis in Caenorhabditis elegans. In particular, condensin promotes both meiotic chromosome condensation after crossover recombination and the remodeling of sister chromatids. Condensin helps resolve cohesin-independent linkages between sister chromatids and alleviates recombination-independent linkages between homologues. The safeguarding of chromosome resolution by condensin permits chromosome segregation and is crucial for the formation of discrete, individualized bivalent chromosomes. |
format | Text |
id | pubmed-2172564 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2004 |
publisher | The Rockefeller University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-21725642008-03-05 Condensin restructures chromosomes in preparation for meiotic divisions Chan, Raymond C. Severson, Aaron F. Meyer, Barbara J. J Cell Biol Research Articles The production of haploid gametes from diploid germ cells requires two rounds of meiotic chromosome segregation after one round of replication. Accurate meiotic chromosome segregation involves the remodeling of each pair of homologous chromosomes around the site of crossover into a highly condensed and ordered structure. We showed that condensin, the protein complex needed for mitotic chromosome compaction, restructures chromosomes during meiosis in Caenorhabditis elegans. In particular, condensin promotes both meiotic chromosome condensation after crossover recombination and the remodeling of sister chromatids. Condensin helps resolve cohesin-independent linkages between sister chromatids and alleviates recombination-independent linkages between homologues. The safeguarding of chromosome resolution by condensin permits chromosome segregation and is crucial for the formation of discrete, individualized bivalent chromosomes. The Rockefeller University Press 2004-11-22 /pmc/articles/PMC2172564/ /pubmed/15557118 http://dx.doi.org/10.1083/jcb.200408061 Text en Copyright © 2004, The Rockefeller University Press https://creativecommons.org/licenses/by-nc-sa/4.0/This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/ (https://creativecommons.org/licenses/by-nc-sa/4.0/) ). |
spellingShingle | Research Articles Chan, Raymond C. Severson, Aaron F. Meyer, Barbara J. Condensin restructures chromosomes in preparation for meiotic divisions |
title | Condensin restructures chromosomes in preparation for meiotic divisions |
title_full | Condensin restructures chromosomes in preparation for meiotic divisions |
title_fullStr | Condensin restructures chromosomes in preparation for meiotic divisions |
title_full_unstemmed | Condensin restructures chromosomes in preparation for meiotic divisions |
title_short | Condensin restructures chromosomes in preparation for meiotic divisions |
title_sort | condensin restructures chromosomes in preparation for meiotic divisions |
topic | Research Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2172564/ https://www.ncbi.nlm.nih.gov/pubmed/15557118 http://dx.doi.org/10.1083/jcb.200408061 |
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