Cargando…

A foldable CFTRΔF508 biogenic intermediate accumulates upon inhibition of the Hsc70–CHIP E3 ubiquitin ligase

CFTRΔF508 exhibits a correctable protein-folding defect that leads to its misfolding and premature degradation, which is the cause of cystic fibrosis (CF). Herein we report on the characterization of the CFTRΔF508 biogenic intermediate that is selected for proteasomal degradation and identification...

Descripción completa

Detalles Bibliográficos
Autores principales: Younger, J. Michael, Ren, Hong-Yu, Chen, Liling, Fan, Chun-Yang, Fields, Andrea, Patterson, Cam, Cyr, Douglas M.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2004
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2172621/
https://www.ncbi.nlm.nih.gov/pubmed/15611333
http://dx.doi.org/10.1083/jcb.200410065

Ejemplares similares