Anthrax toxin rafts into cells

Anthrax toxin binds to a plasma membrane receptor and after endocytosis exerts its deadly effects on the cell. Until now, however, the mechanism of initial toxin uptake was unknown. In this issue, Abrami et al. (2003) demonstrate that toxin oligomerization clusters the anthrax receptor into lipid ra...

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Detalles Bibliográficos
Autor principal: Kurzchalia, Teymuras
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2003
Materias:
Comment
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2172653/
https://www.ncbi.nlm.nih.gov/pubmed/12566425
http://dx.doi.org/10.1083/jcb.200301032
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author Kurzchalia, Teymuras
author_facet Kurzchalia, Teymuras
author_sort Kurzchalia, Teymuras
collection PubMed
description Anthrax toxin binds to a plasma membrane receptor and after endocytosis exerts its deadly effects on the cell. Until now, however, the mechanism of initial toxin uptake was unknown. In this issue, Abrami et al. (2003) demonstrate that toxin oligomerization clusters the anthrax receptor into lipid rafts and this complex is internalized via the clathrin-dependent pathway.
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spelling pubmed-21726532008-05-01 Anthrax toxin rafts into cells Kurzchalia, Teymuras J Cell Biol Comment Anthrax toxin binds to a plasma membrane receptor and after endocytosis exerts its deadly effects on the cell. Until now, however, the mechanism of initial toxin uptake was unknown. In this issue, Abrami et al. (2003) demonstrate that toxin oligomerization clusters the anthrax receptor into lipid rafts and this complex is internalized via the clathrin-dependent pathway. The Rockefeller University Press 2003-02-03 /pmc/articles/PMC2172653/ /pubmed/12566425 http://dx.doi.org/10.1083/jcb.200301032 Text en Copyright © 2003, The Rockefeller University Press This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Comment
Kurzchalia, Teymuras
Anthrax toxin rafts into cells
title Anthrax toxin rafts into cells
title_full Anthrax toxin rafts into cells
title_fullStr Anthrax toxin rafts into cells
title_full_unstemmed Anthrax toxin rafts into cells
title_short Anthrax toxin rafts into cells
title_sort anthrax toxin rafts into cells
topic Comment
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2172653/
https://www.ncbi.nlm.nih.gov/pubmed/12566425
http://dx.doi.org/10.1083/jcb.200301032
work_keys_str_mv AT kurzchaliateymuras anthraxtoxinraftsintocells

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