Dynactin polices two-way organelle traffic

How is the bidirectional motion of organelles controlled? In this issue, Deacon et al. (2003) reveal the unexpected finding that dynactin (previously known to control dynein-based motility) binds to kinesin II and regulates anterograde movement of Xenopus melanosomes. This result suggests that dynac...

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Detalles Bibliográficos
Autor principal: Dell, Karen R.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2003
Materias:
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2172678/
https://www.ncbi.nlm.nih.gov/pubmed/12566424
http://dx.doi.org/10.1083/jcb.200301040
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Sumario:How is the bidirectional motion of organelles controlled? In this issue, Deacon et al. (2003) reveal the unexpected finding that dynactin (previously known to control dynein-based motility) binds to kinesin II and regulates anterograde movement of Xenopus melanosomes. This result suggests that dynactin may be a key player in coordinating vesicle traffic in this system.

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