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Roles of Gβγ in membrane recruitment and activation of p110γ/p101 phosphoinositide 3-kinase γ

Receptor-regulated class I phosphoinositide 3-kinases (PI3K) phosphorylate the membrane lipid phosphatidylinositol (PtdIns)-4,5-P(2) to PtdIns-3,4,5-P(3). This, in turn, recruits and activates cytosolic effectors with PtdIns-3,4,5-P(3)–binding pleckstrin homology (PH) domains, thereby controlling im...

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Detalles Bibliográficos
Autores principales:	Brock, Carsten, Schaefer, Michael, Reusch, H. Peter, Czupalla, Cornelia, Michalke, Manuela, Spicher, Karsten, Schultz, Günter, Nürnberg, Bernd
Formato:	Texto
Lenguaje:	English
Publicado:	The Rockefeller University Press 2003
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2172741/ https://www.ncbi.nlm.nih.gov/pubmed/12507995 http://dx.doi.org/10.1083/jcb.200210115

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