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Amyloidogenic processing of the Alzheimer β-amyloid precursor protein depends on lipid rafts

Formation of senile plaques containing the β-amyloid peptide (Aβ) derived from the amyloid precursor protein (APP) is an invariant feature of Alzheimer's disease (AD). APP is cleaved either by β-secretase or by α-secretase to initiate amyloidogenic (release of Aβ) or nonamyloidogenic processing...

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Detalles Bibliográficos
Autores principales:	Ehehalt, Robert, Keller, Patrick, Haass, Christian, Thiele, Christoph, Simons, Kai
Formato:	Texto
Lenguaje:	English
Publicado:	The Rockefeller University Press 2003
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2172747/ https://www.ncbi.nlm.nih.gov/pubmed/12515826 http://dx.doi.org/10.1083/jcb.200207113

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