PAK1 phosphorylation of MEK1 regulates fibronectin-stimulated MAPK activation

Activation of the Ras–MAPK signal transduction pathway is necessary for biological responses both to growth factors and ECM. Here, we provide evidence that phosphorylation of S298 of MAPK kinase 1 (MEK1) by p21-activated kinase (PAK) is a site of convergence for integrin and growth factor signaling....

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Detalles Bibliográficos
Autores principales: Slack-Davis, Jill K., Eblen, Scott T., Zecevic, Maja, Boerner, Scott A., Tarcsafalvi, Adel, Diaz, H. Bruce, Marshall, Mark S., Weber, Michael J., Parsons, J. Thomas, Catling, Andrew D.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2003
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2172784/
https://www.ncbi.nlm.nih.gov/pubmed/12876277
http://dx.doi.org/10.1083/jcb.200212141

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