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Regulation of phospholipase D1 subcellular cycling through coordination of multiple membrane association motifs
The signaling enzyme phospholipase D1 (PLD1) facilitates membrane vesicle trafficking. Here, we explore how PLD1 subcellular localization is regulated via Phox homology (PX) and pleckstrin homology (PH) domains and a PI4,5P(2)-binding site critical for its activation. PLD1 localized to perinuclear e...
Autores principales: | Du, Guangwei, Altshuller, Yelena M., Vitale, Nicolas, Huang, Ping, Chasserot-Golaz, Sylvette, Morris, Andrew J., Bader, Marie-France, Frohman, Michael A. |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
The Rockefeller University Press
2003
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2172799/ https://www.ncbi.nlm.nih.gov/pubmed/12876278 http://dx.doi.org/10.1083/jcb.200302033 |
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