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GPI-anchored uPAR requires Endo180 for rapid directional sensing during chemotaxis

Urokinase-type plasminogen activator (uPA) and its receptor (uPAR) play an important role in cell guidance and chemotaxis during normal and pathological events. uPAR is GPI-anchored and the mechanism by which it transmits intracellular polarity cues across the plasma membrane during directional sens...

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Detalles Bibliográficos
Autores principales: Sturge, Justin, Wienke, Dirk, East, Lucy, Jones, Gareth E., Isacke, Clare M.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2003
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2172817/
https://www.ncbi.nlm.nih.gov/pubmed/12952933
http://dx.doi.org/10.1083/jcb.200302124