Wnt-5a inhibits the canonical Wnt pathway by promoting GSK-3–independent β-catenin degradation

Wnts are secreted signaling molecules that can transduce their signals through several different pathways. Wnt-5a is considered a noncanonical Wnt as it does not signal by stabilizing β-catenin in many biological systems. We have uncovered a new noncanonical pathway through which Wnt-5a antagonizes...

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Autores principales: Topol, Lilia, Jiang, Xueyuan, Choi, Hosoon, Garrett-Beal, Lisa, Carolan, Peter J., Yang, Yingzi
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2003
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2172823/
https://www.ncbi.nlm.nih.gov/pubmed/12952940
http://dx.doi.org/10.1083/jcb.200303158
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author Topol, Lilia
Jiang, Xueyuan
Choi, Hosoon
Garrett-Beal, Lisa
Carolan, Peter J.
Yang, Yingzi
author_facet Topol, Lilia
Jiang, Xueyuan
Choi, Hosoon
Garrett-Beal, Lisa
Carolan, Peter J.
Yang, Yingzi
author_sort Topol, Lilia
collection PubMed
description Wnts are secreted signaling molecules that can transduce their signals through several different pathways. Wnt-5a is considered a noncanonical Wnt as it does not signal by stabilizing β-catenin in many biological systems. We have uncovered a new noncanonical pathway through which Wnt-5a antagonizes the canonical Wnt pathway by promoting the degradation of β-catenin. This pathway is Siah2 and APC dependent, but GSK-3 and β-TrCP independent. Furthermore, we provide evidence that Wnt-5a also acts in vivo to promote β-catenin degradation in regulating mammalian limb development and possibly in suppressing tumor formation.
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spelling pubmed-21728232008-05-01 Wnt-5a inhibits the canonical Wnt pathway by promoting GSK-3–independent β-catenin degradation Topol, Lilia Jiang, Xueyuan Choi, Hosoon Garrett-Beal, Lisa Carolan, Peter J. Yang, Yingzi J Cell Biol Article Wnts are secreted signaling molecules that can transduce their signals through several different pathways. Wnt-5a is considered a noncanonical Wnt as it does not signal by stabilizing β-catenin in many biological systems. We have uncovered a new noncanonical pathway through which Wnt-5a antagonizes the canonical Wnt pathway by promoting the degradation of β-catenin. This pathway is Siah2 and APC dependent, but GSK-3 and β-TrCP independent. Furthermore, we provide evidence that Wnt-5a also acts in vivo to promote β-catenin degradation in regulating mammalian limb development and possibly in suppressing tumor formation. The Rockefeller University Press 2003-09-01 /pmc/articles/PMC2172823/ /pubmed/12952940 http://dx.doi.org/10.1083/jcb.200303158 Text en This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Article
Topol, Lilia
Jiang, Xueyuan
Choi, Hosoon
Garrett-Beal, Lisa
Carolan, Peter J.
Yang, Yingzi
Wnt-5a inhibits the canonical Wnt pathway by promoting GSK-3–independent β-catenin degradation
title Wnt-5a inhibits the canonical Wnt pathway by promoting GSK-3–independent β-catenin degradation
title_full Wnt-5a inhibits the canonical Wnt pathway by promoting GSK-3–independent β-catenin degradation
title_fullStr Wnt-5a inhibits the canonical Wnt pathway by promoting GSK-3–independent β-catenin degradation
title_full_unstemmed Wnt-5a inhibits the canonical Wnt pathway by promoting GSK-3–independent β-catenin degradation
title_short Wnt-5a inhibits the canonical Wnt pathway by promoting GSK-3–independent β-catenin degradation
title_sort wnt-5a inhibits the canonical wnt pathway by promoting gsk-3–independent β-catenin degradation
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2172823/
https://www.ncbi.nlm.nih.gov/pubmed/12952940
http://dx.doi.org/10.1083/jcb.200303158
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