Wnt-5a inhibits the canonical Wnt pathway by promoting GSK-3–independent β-catenin degradation

Wnts are secreted signaling molecules that can transduce their signals through several different pathways. Wnt-5a is considered a noncanonical Wnt as it does not signal by stabilizing β-catenin in many biological systems. We have uncovered a new noncanonical pathway through which Wnt-5a antagonizes...

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Detalles Bibliográficos
Autores principales: Topol, Lilia, Jiang, Xueyuan, Choi, Hosoon, Garrett-Beal, Lisa, Carolan, Peter J., Yang, Yingzi
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2003
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2172823/
https://www.ncbi.nlm.nih.gov/pubmed/12952940
http://dx.doi.org/10.1083/jcb.200303158

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