When Wnts antagonize Wnts

Secreted Wnt ligands appear to activate a variety of signaling pathways. Two papers in this issue now present genetic evidence that “noncanonical” Wnt signaling inhibits the “canonical” Wnt/β-catenin pathway. Westfall et al. (2003a) show that zebrafish embryos lacking maternal Wnt-5 function are dor...

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Detalles Bibliográficos
Autores principales: Weidinger, Gilbert, Moon, Randall T.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2003
Materias:
Comment
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2172824/
https://www.ncbi.nlm.nih.gov/pubmed/12952929
http://dx.doi.org/10.1083/jcb.200307181
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author Weidinger, Gilbert
Moon, Randall T.
author_facet Weidinger, Gilbert
Moon, Randall T.
author_sort Weidinger, Gilbert
collection PubMed
description Secreted Wnt ligands appear to activate a variety of signaling pathways. Two papers in this issue now present genetic evidence that “noncanonical” Wnt signaling inhibits the “canonical” Wnt/β-catenin pathway. Westfall et al. (2003a) show that zebrafish embryos lacking maternal Wnt-5 function are dorsalized due to ectopic activation of β-catenin, whereas Topol et al. (2003) report that chondrogenesis in the distal mouse limb bud depends on inhibition of Wnt/β-catenin signaling by a paralogue of Wnt-5. These studies present the first genetic confirmation of the previous hypothesis that vertebrate Wnt signaling pathways can act in an antagonistic manner.
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spelling pubmed-21728242008-05-01 When Wnts antagonize Wnts Weidinger, Gilbert Moon, Randall T. J Cell Biol Comment Secreted Wnt ligands appear to activate a variety of signaling pathways. Two papers in this issue now present genetic evidence that “noncanonical” Wnt signaling inhibits the “canonical” Wnt/β-catenin pathway. Westfall et al. (2003a) show that zebrafish embryos lacking maternal Wnt-5 function are dorsalized due to ectopic activation of β-catenin, whereas Topol et al. (2003) report that chondrogenesis in the distal mouse limb bud depends on inhibition of Wnt/β-catenin signaling by a paralogue of Wnt-5. These studies present the first genetic confirmation of the previous hypothesis that vertebrate Wnt signaling pathways can act in an antagonistic manner. The Rockefeller University Press 2003-09-01 /pmc/articles/PMC2172824/ /pubmed/12952929 http://dx.doi.org/10.1083/jcb.200307181 Text en Copyright © 2003, The Rockefeller University Press This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Comment
Weidinger, Gilbert
Moon, Randall T.
When Wnts antagonize Wnts
title When Wnts antagonize Wnts
title_full When Wnts antagonize Wnts
title_fullStr When Wnts antagonize Wnts
title_full_unstemmed When Wnts antagonize Wnts
title_short When Wnts antagonize Wnts
title_sort when wnts antagonize wnts
topic Comment
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2172824/
https://www.ncbi.nlm.nih.gov/pubmed/12952929
http://dx.doi.org/10.1083/jcb.200307181
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