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Mitochondrial targeting and a novel transmembrane arrest of Alzheimer's amyloid precursor protein impairs mitochondrial function in neuronal cells

Alzheimer's amyloid precursor protein 695 (APP) is a plasma membrane protein, which is known to be the source of the toxic amyloid β (Aβ) peptide associated with the pathogenesis of Alzheimer's disease (AD). Here we demonstrate that by virtue of its chimeric NH(2)-terminal signal, APP is a...

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Detalles Bibliográficos
Autores principales:	Anandatheerthavarada, Hindupur K., Biswas, Gopa, Robin, Marie-Anne, Avadhani, Narayan G.
Formato:	Texto
Lenguaje:	English
Publicado:	The Rockefeller University Press 2003
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2172865/ https://www.ncbi.nlm.nih.gov/pubmed/12695498 http://dx.doi.org/10.1083/jcb.200207030

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