Cargando…

Abnormal neurofilament transport caused by targeted disruption of neuronal kinesin heavy chain KIF5A

To test the hypothesis that fast anterograde molecular motor proteins power the slow axonal transport of neurofilaments (NFs), we used homologous recombination to generate mice lacking the neuronal-specific conventional kinesin heavy chain, KIF5A. Because null KIF5A mutants die immediately after bir...

Descripción completa

Detalles Bibliográficos
Autores principales:	Xia, Chun-Hong, Roberts, Elizabeth A., Her, Lu-Shiun, Liu, Xinran, Williams, David S., Cleveland, Don W., Goldstein, Lawrence S.B.
Formato:	Texto
Lenguaje:	English
Publicado:	The Rockefeller University Press 2003
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2172877/ https://www.ncbi.nlm.nih.gov/pubmed/12682084 http://dx.doi.org/10.1083/jcb.200301026

Ejemplares similares

Defective Kinesin Heavy Chain Behavior in Mouse Kinesin Light Chain Mutants
por: Rahman, Amena, et al.
Publicado: (1999)

A hereditary spastic paraplegia mutation in kinesin-1A/KIF5A disrupts neurofilament transport
por: Wang, Lina, et al.
Publicado: (2010)

Novel Dendritic Kinesin Sorting Identified by Different Process Targeting of Two Related Kinesins: KIF21A and KIF21B
por: Marszalek, Joseph R., et al.
Publicado: (1999)

Kinesin Light Chains Are Essential for Axonal Transport in Drosophila
por: Gindhart, Joseph G., et al.
Publicado: (1998)

A role for kinesin heavy chain in controlling vesicle transport into dendrites in Drosophila
por: Henthorn, Kristina Schimmelpfeng, et al.
Publicado: (2011)

Neurofilament heavy chain side arm phosphorylation regulates axonal transport of neurofilaments
por: Ackerley, Steven, et al.
Publicado: (2003)

KIF2 is a new microtubule-based anterograde motor that transports membranous organelles distinct from those carried by kinesin heavy chain or KIF3A/B
Publicado: (1995)

Neurofilament-dependent Radial Growth of Motor Axons and Axonal Organization of Neurofilaments Does Not Require the Neurofilament Heavy Subunit (NF-H) or Its Phosphorylation
por: Rao, Mala V., et al.
Publicado: (1998)

CENP-meta, an Essential Kinetochore Kinesin Required for the Maintenance of Metaphase Chromosome Alignment in Drosophila
por: Yucel, Jennifer K., et al.
Publicado: (2000)

Axonal transport of mitochondria requires milton to recruit kinesin heavy chain and is light chain independent
por: Glater, Elizabeth E., et al.
Publicado: (2006)

Kinesin-II Is Required for Axonal Transport of Choline Acetyltransferase in Drosophila
por: Ray, Krishanu, et al.
Publicado: (1999)

Hedgehog-induced ciliary trafficking of kinesin-4 motor KIF7 requires intraflagellar transport but not KIF7’s microtubule binding
por: Yue, Yang, et al.
Publicado: (2022)

The kinesin KIF1C transports APC-dependent mRNAs to cell protrusions
por: Pichon, Xavier, et al.
Publicado: (2021)

Inhibition of kinesin-driven microtubule motility by monoclonal antibodies to kinesin heavy chains
Publicado: (1988)

Concerted action of kinesins KIF5B and KIF13B promotes efficient secretory vesicle transport to microtubule plus ends
por: Serra-Marques, Andrea, et al.
Publicado: (2020)

KAP is the neuronal organelle adaptor for Kinesin-2 KIF3AB and KIF3AC
por: Garbouchian, Alex, et al.
Publicado: (2022)

Neurofilament levels in patients with neurological diseases: A comparison of neurofilament light and heavy chain levels
por: Kušnierová, Pavlína, et al.
Publicado: (2019)

Altered chemomechanical coupling causes impaired motility of the kinesin-4 motors KIF27 and KIF7
por: Yue, Yang, et al.
Publicado: (2018)

Kinesin-binding protein ensures accurate chromosome segregation by buffering KIF18A and KIF15
por: Malaby, Heidi L.H., et al.
Publicado: (2019)

Septin 9 interacts with kinesin KIF17 and interferes with the mechanism of NMDA receptor cargo binding and transport
por: Bai, Xiaobo, et al.
Publicado: (2016)

Motor domain-mediated autoinhibition dictates axonal transport by the kinesin UNC-104/KIF1A
por: Cong, Dezi, et al.
Publicado: (2021)

KIF11 and KIF15 mitotic kinesins are potential therapeutic vulnerabilities for malignant peripheral nerve sheath tumors
por: Terribas, Ernest, et al.
Publicado: (2020)

Kinesin Superfamily Protein 3 (Kif3) Motor Transports Fodrin-Associating Vesicles Important for Neurite Building
por: Takeda, Sen, et al.
Publicado: (2000)

A standardized kinesin nomenclature
por: Lawrence, Carolyn J., et al.
Publicado: (2004)

The Kinesin-12 Kif15 is a processive track-switching tetramer
por: Drechsler, Hauke, et al.
Publicado: (2014)

The role of kinesin KIF18A in the invasion and metastasis of hepatocellular carcinoma
por: Luo, Weiwei, et al.
Publicado: (2018)

Modulation of estrogen related receptor alpha activity by the kinesin KIF17
por: Seneviratne, AM Pramodh Bandara, et al.
Publicado: (2017)

Structural basis of mechano-chemical coupling by the mitotic kinesin KIF14
por: Benoit, Matthieu P.M.H., et al.
Publicado: (2021)

Deletion of the Pseudorabies Virus gE/gI-US9p complex disrupts kinesin KIF1A and KIF5C recruitment during egress, and alters the properties of microtubule-dependent transport in vitro
por: Diwaker, Drishya, et al.
Publicado: (2020)

Serum neurofilament heavy chains as early marker of motor neuron degeneration
por: De Schaepdryver, Maxim, et al.
Publicado: (2019)

Paradigm lost: milton connects kinesin heavy chain to miro on mitochondria
por: Rice, Sarah E., et al.
Publicado: (2006)

Tumor Necrosis Factor Induces Hyperphosphorylation of Kinesin Light Chain and Inhibits Kinesin-Mediated Transport of Mitochondria
por: De Vos, Kurt, et al.
Publicado: (2000)

Structural insights into human Kif7, a kinesin involved in Hedgehog signalling
por: Klejnot, Marta, et al.
Publicado: (2012)

Molecular Motor Proteins of the Kinesin Superfamily Proteins (KIFs): Structure, Cargo and Disease
por: Seog, Dae-Hyun, et al.
Publicado: (2004)

Autoinhibition of the kinesin-2 motor KIF17 via dual intramolecular mechanisms
por: Hammond, Jennetta W., et al.
Publicado: (2010)

TRIM3 Regulates the Motility of the Kinesin Motor Protein KIF21B
por: Labonté, Dorthe, et al.
Publicado: (2013)

Motility and microtubule depolymerization mechanisms of the Kinesin-8 motor, KIF19A
por: Wang, Doudou, et al.
Publicado: (2016)

Observations on spontaneous tumor formation in mice overexpressing mitotic kinesin Kif14
por: Sishtla, Kamakshi, et al.
Publicado: (2018)

Kinesin-4 KIF21B is a potent microtubule pausing factor
por: van Riel, Wilhelmina E, et al.
Publicado: (2017)

Testis‐enriched kinesin KIF9 is important for progressive motility in mouse spermatozoa
por: Miyata, Haruhiko, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_dgo6b0jtafs7bc0i07fi449i5b