Modeling network dynamics: the lac operon, a case study

We use the lac operon in Escherichia coli as a prototype system to illustrate the current state, applicability, and limitations of modeling the dynamics of cellular networks. We integrate three different levels of description (molecular, cellular, and that of cell population) into a single model, wh...

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Detalles Bibliográficos
Autores principales: Vilar, José M.G., Guet, Călin C., Leibler, Stanislas
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2003
Materias:
Mini-Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2172934/
https://www.ncbi.nlm.nih.gov/pubmed/12743100
http://dx.doi.org/10.1083/jcb.200301125
Descripción
Sumario:We use the lac operon in Escherichia coli as a prototype system to illustrate the current state, applicability, and limitations of modeling the dynamics of cellular networks. We integrate three different levels of description (molecular, cellular, and that of cell population) into a single model, which seems to capture many experimental aspects of the system.

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