Mitochondria to nucleus stress signaling: a distinctive mechanism of NFκB/Rel activation through calcineurin-mediated inactivation of IκBβ

Mitochondrial genetic and metabolic stress causes activation of calcineurin (Cn), NFAT, ATF2, and NFκB/Rel factors, which collectively alter the expression of an array of nuclear genes. We demonstrate here that mitochondrial stress–induced activation of NFκB/Rel factors involves inactivation of IκBβ...

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Detalles Bibliográficos
Autores principales: Biswas, Gopa, Anandatheerthavarada, Hindupur K., Zaidi, Mone, Avadhani, Narayan G.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2003
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2172940/
https://www.ncbi.nlm.nih.gov/pubmed/12732617
http://dx.doi.org/10.1083/jcb.200211104

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2172940/
https://www.ncbi.nlm.nih.gov/pubmed/12732617
http://dx.doi.org/10.1083/jcb.200211104

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