Mutant DMPK 3′-UTR transcripts disrupt C2C12 myogenic differentiation by compromising MyoD

Myotonic dystrophy (DM) is caused by two similar noncoding repeat expansion mutations (DM1 and DM2). It is thought that both mutations produce pathogenic RNA molecules that accumulate in nuclear foci. The DM1 mutation is a CTG expansion in the 3′ untranslated region (3′-UTR) of dystrophia myotonica...

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Detalles Bibliográficos
Autores principales: Amack, Jeffrey D., Reagan, Shannon R., Mahadevan, Mani S.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2002
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2173077/
https://www.ncbi.nlm.nih.gov/pubmed/12427866
http://dx.doi.org/10.1083/jcb.200206020

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2173077/
https://www.ncbi.nlm.nih.gov/pubmed/12427866
http://dx.doi.org/10.1083/jcb.200206020

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