Wnt signaling promotes oncogenic transformation by inhibiting c-Myc–induced apoptosis

Aberrant activation of the Wnt/β-catenin signaling pathway is associated with numerous human cancers and often correlates with the overexpression or amplification of the c-myc oncogene. Paradoxical to the cellular transformation potential of c-Myc is its ability to also induce apoptosis. Using an in...

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Detalles Bibliográficos
Autores principales: You, Zongbing, Saims, Daniel, Chen, Shaoqiong, Zhang, Zhaocheng, Guttridge, Denis C., Guan, Kun-liang, MacDougald, Ormond A., Brown, Anthony M.C., Evan, Gerard, Kitajewski, Jan, Wang, Cun-Yu
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2002
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2173296/
https://www.ncbi.nlm.nih.gov/pubmed/11980918
http://dx.doi.org/10.1083/jcb.200201110

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