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Phosphorylation of the AP2 μ subunit by AAK1 mediates high affinity binding to membrane protein sorting signals
During receptor-mediated endocytosis, AP2 complexes act as a bridge between the cargo membrane proteins and the clathrin coat by binding to sorting signals via the μ2 subunit and to clathrin via the β subunit. Here we show that binding of AP2 to sorting signals in vitro is regulated by phosphorylati...
Autores principales: | Ricotta, Doris, Conner, Sean D., Schmid, Sandra L., von Figura, Kurt, Höning, Stefan |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
The Rockefeller University Press
2002
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2173304/ https://www.ncbi.nlm.nih.gov/pubmed/11877457 http://dx.doi.org/10.1083/jcb.200111068 |
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