Nfat: ubiquitous regulator of cell differentiation and adaptation

The nuclear factor of activated T cells (NFAT) proteins are a family of transcription factors whose activation is controlled by calcineurin, a Ca(2+)-dependent phosphatase. Originally identified in T cells as inducers of cytokine gene expression, NFAT proteins play varied roles in cells outside of t...

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Detalles Bibliográficos
Autores principales: Horsley, Valerie, Pavlath, Grace K.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2002
Materias:
Mini-Reviews
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2173310/
https://www.ncbi.nlm.nih.gov/pubmed/11877454
http://dx.doi.org/10.1083/jcb.200111073
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author Horsley, Valerie
Pavlath, Grace K.
author_facet Horsley, Valerie
Pavlath, Grace K.
author_sort Horsley, Valerie
collection PubMed
description The nuclear factor of activated T cells (NFAT) proteins are a family of transcription factors whose activation is controlled by calcineurin, a Ca(2+)-dependent phosphatase. Originally identified in T cells as inducers of cytokine gene expression, NFAT proteins play varied roles in cells outside of the immune system. This review addresses the recent data implicating NFAT in the control of gene expression influencing the development and adaptation of numerous mammalian cell types.
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spelling pubmed-21733102008-05-01 Nfat: ubiquitous regulator of cell differentiation and adaptation Horsley, Valerie Pavlath, Grace K. J Cell Biol Mini-Reviews The nuclear factor of activated T cells (NFAT) proteins are a family of transcription factors whose activation is controlled by calcineurin, a Ca(2+)-dependent phosphatase. Originally identified in T cells as inducers of cytokine gene expression, NFAT proteins play varied roles in cells outside of the immune system. This review addresses the recent data implicating NFAT in the control of gene expression influencing the development and adaptation of numerous mammalian cell types. The Rockefeller University Press 2002-03-04 /pmc/articles/PMC2173310/ /pubmed/11877454 http://dx.doi.org/10.1083/jcb.200111073 Text en Copyright © 2002, The Rockefeller University Press This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Mini-Reviews
Horsley, Valerie
Pavlath, Grace K.
Nfat: ubiquitous regulator of cell differentiation and adaptation
title Nfat: ubiquitous regulator of cell differentiation and adaptation
title_full Nfat: ubiquitous regulator of cell differentiation and adaptation
title_fullStr Nfat: ubiquitous regulator of cell differentiation and adaptation
title_full_unstemmed Nfat: ubiquitous regulator of cell differentiation and adaptation
title_short Nfat: ubiquitous regulator of cell differentiation and adaptation
title_sort nfat: ubiquitous regulator of cell differentiation and adaptation
topic Mini-Reviews
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2173310/
https://www.ncbi.nlm.nih.gov/pubmed/11877454
http://dx.doi.org/10.1083/jcb.200111073
work_keys_str_mv AT horsleyvalerie nfatubiquitousregulatorofcelldifferentiationandadaptation
AT pavlathgracek nfatubiquitousregulatorofcelldifferentiationandadaptation

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