Hitchhiking fads en route to peroxisomes

A unique aspect of protein translocation across the peroxisomal membrane is that folded and oligomeric proteins get across this membrane (Purdue and Lazarow, 2001). The generality of this rule, its specific features, and its mechanism are not fully understood. A paper in this issue addresses, in a v...

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Detalles Bibliográficos
Autor principal: Subramani, Suresh
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2002
Materias:
Comment
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2173331/
https://www.ncbi.nlm.nih.gov/pubmed/11827979
http://dx.doi.org/10.1083/jcb.200112122
Descripción
Sumario:A unique aspect of protein translocation across the peroxisomal membrane is that folded and oligomeric proteins get across this membrane (Purdue and Lazarow, 2001). The generality of this rule, its specific features, and its mechanism are not fully understood. A paper in this issue addresses, in a very thorough fashion, the assembly, cofactor binding, and import of an oligomeric protein, acyl-CoA oxidase (Aox), into the peroxisome matrix (Titorenko et al., 2002, this issue).

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