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Direct activation of PDE5 by cGMP: long-term effects within NO/cGMP signaling

In platelets, the nitric oxide (NO)–induced cGMP response is indicative of a highly regulated interplay of cGMP formation and cGMP degradation. Recently, we showed that within the NO-induced cGMP response in human platelets, activation and phosphorylation of phosphodiesterase type 5 (PDE5) occurred....

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Detalles Bibliográficos
Autores principales:	Mullershausen, Florian, Friebe, Andreas, Feil, Robert, Thompson, W. Joseph, Hofmann, Franz, Koesling, Doris
Formato:	Texto
Lenguaje:	English
Publicado:	The Rockefeller University Press 2003
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2173359/ https://www.ncbi.nlm.nih.gov/pubmed/12604588 http://dx.doi.org/10.1083/jcb.200211041

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