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Insulin receptor substrate-2 maintains predominance of anabolic function over catabolic function of osteoblasts
Insulin receptor substrates (IRS-1 and IRS-2) are essential for intracellular signaling by insulin and insulin-like growth factor-I (IGF-I), anabolic regulators of bone metabolism. Although mice lacking the IRS-2 gene (IRS-2 (−/−) mice) developed normally, they exhibited osteopenia with decreased bo...
Autores principales: | , , , , , , , , , , |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
The Rockefeller University Press
2002
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2173484/ https://www.ncbi.nlm.nih.gov/pubmed/12379806 http://dx.doi.org/10.1083/jcb.200204046 |