Sorting it out: AP-2 and alternate clathrin adaptors in endocytic cargo selection

The AP-2 adaptor complex is widely viewed as a linchpin molecule in clathrin-mediated endocytosis, simultaneously binding both clathrin and receptors. This dual interaction couples cargo capture with clathrin coat assembly, but it has now been discovered that the association with cargo is tightly re...

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Detalles Bibliográficos
Autor principal: Traub, Linton M.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2003
Materias:
Mini-Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2173531/
https://www.ncbi.nlm.nih.gov/pubmed/14581447
http://dx.doi.org/10.1083/jcb.200309175
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author Traub, Linton M.
author_facet Traub, Linton M.
author_sort Traub, Linton M.
collection PubMed
description The AP-2 adaptor complex is widely viewed as a linchpin molecule in clathrin-mediated endocytosis, simultaneously binding both clathrin and receptors. This dual interaction couples cargo capture with clathrin coat assembly, but it has now been discovered that the association with cargo is tightly regulated. Remarkably, AP-2 is not obligatory for all clathrin-mediated uptake, and several alternate adaptors appear to perform similar sorting and assembly functions at the clathrin bud site.
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spelling pubmed-21735312008-05-01 Sorting it out: AP-2 and alternate clathrin adaptors in endocytic cargo selection Traub, Linton M. J Cell Biol Mini-Review The AP-2 adaptor complex is widely viewed as a linchpin molecule in clathrin-mediated endocytosis, simultaneously binding both clathrin and receptors. This dual interaction couples cargo capture with clathrin coat assembly, but it has now been discovered that the association with cargo is tightly regulated. Remarkably, AP-2 is not obligatory for all clathrin-mediated uptake, and several alternate adaptors appear to perform similar sorting and assembly functions at the clathrin bud site. The Rockefeller University Press 2003-10-27 /pmc/articles/PMC2173531/ /pubmed/14581447 http://dx.doi.org/10.1083/jcb.200309175 Text en Copyright © 2003, The Rockefeller University Press This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Mini-Review
Traub, Linton M.
Sorting it out: AP-2 and alternate clathrin adaptors in endocytic cargo selection
title Sorting it out: AP-2 and alternate clathrin adaptors in endocytic cargo selection
title_full Sorting it out: AP-2 and alternate clathrin adaptors in endocytic cargo selection
title_fullStr Sorting it out: AP-2 and alternate clathrin adaptors in endocytic cargo selection
title_full_unstemmed Sorting it out: AP-2 and alternate clathrin adaptors in endocytic cargo selection
title_short Sorting it out: AP-2 and alternate clathrin adaptors in endocytic cargo selection
title_sort sorting it out: ap-2 and alternate clathrin adaptors in endocytic cargo selection
topic Mini-Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2173531/
https://www.ncbi.nlm.nih.gov/pubmed/14581447
http://dx.doi.org/10.1083/jcb.200309175
work_keys_str_mv AT traublintonm sortingitoutap2andalternateclathrinadaptorsinendocyticcargoselection

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