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Proximal location of mouse prostate epithelial stem cells: a model of prostatic homeostasis

Stem cells are believed to regulate normal prostatic homeostasis and to play a role in the etiology of prostate cancer and benign prostatic hyperplasia. We show here that the proximal region of mouse prostatic ducts is enriched in a subpopulation of epithelial cells that exhibit three important attr...

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Autores principales: Tsujimura, Akira, Koikawa, Yasuhiro, Salm, Sarah, Takao, Tetsuya, Coetzee, Sandra, Moscatelli, David, Shapiro, Ellen, Lepor, Herbert, Sun, Tung-Tien, Wilson, E. Lynette
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2002
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2173539/
https://www.ncbi.nlm.nih.gov/pubmed/12082083
http://dx.doi.org/10.1083/jcb.200202067
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author Tsujimura, Akira
Koikawa, Yasuhiro
Salm, Sarah
Takao, Tetsuya
Coetzee, Sandra
Moscatelli, David
Shapiro, Ellen
Lepor, Herbert
Sun, Tung-Tien
Wilson, E. Lynette
author_facet Tsujimura, Akira
Koikawa, Yasuhiro
Salm, Sarah
Takao, Tetsuya
Coetzee, Sandra
Moscatelli, David
Shapiro, Ellen
Lepor, Herbert
Sun, Tung-Tien
Wilson, E. Lynette
author_sort Tsujimura, Akira
collection PubMed
description Stem cells are believed to regulate normal prostatic homeostasis and to play a role in the etiology of prostate cancer and benign prostatic hyperplasia. We show here that the proximal region of mouse prostatic ducts is enriched in a subpopulation of epithelial cells that exhibit three important attributes of epithelial stem cells: they are slow cycling, possess a high in vitro proliferative potential, and can reconstitute highly branched glandular ductal structures in collagen gels. We propose a model of prostatic homeostasis in which mouse prostatic epithelial stem cells are concentrated in the proximal region of prostatic ducts while the transit-amplifying cells occupy the distal region of the ducts. This model can account for many biological differences between cells of the proximal and distal regions, and has implications for prostatic disease formation.
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spelling pubmed-21735392008-05-01 Proximal location of mouse prostate epithelial stem cells: a model of prostatic homeostasis Tsujimura, Akira Koikawa, Yasuhiro Salm, Sarah Takao, Tetsuya Coetzee, Sandra Moscatelli, David Shapiro, Ellen Lepor, Herbert Sun, Tung-Tien Wilson, E. Lynette J Cell Biol Article Stem cells are believed to regulate normal prostatic homeostasis and to play a role in the etiology of prostate cancer and benign prostatic hyperplasia. We show here that the proximal region of mouse prostatic ducts is enriched in a subpopulation of epithelial cells that exhibit three important attributes of epithelial stem cells: they are slow cycling, possess a high in vitro proliferative potential, and can reconstitute highly branched glandular ductal structures in collagen gels. We propose a model of prostatic homeostasis in which mouse prostatic epithelial stem cells are concentrated in the proximal region of prostatic ducts while the transit-amplifying cells occupy the distal region of the ducts. This model can account for many biological differences between cells of the proximal and distal regions, and has implications for prostatic disease formation. The Rockefeller University Press 2002-06-24 /pmc/articles/PMC2173539/ /pubmed/12082083 http://dx.doi.org/10.1083/jcb.200202067 Text en Copyright © 2002, The Rockefeller University Press This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Article
Tsujimura, Akira
Koikawa, Yasuhiro
Salm, Sarah
Takao, Tetsuya
Coetzee, Sandra
Moscatelli, David
Shapiro, Ellen
Lepor, Herbert
Sun, Tung-Tien
Wilson, E. Lynette
Proximal location of mouse prostate epithelial stem cells: a model of prostatic homeostasis
title Proximal location of mouse prostate epithelial stem cells: a model of prostatic homeostasis
title_full Proximal location of mouse prostate epithelial stem cells: a model of prostatic homeostasis
title_fullStr Proximal location of mouse prostate epithelial stem cells: a model of prostatic homeostasis
title_full_unstemmed Proximal location of mouse prostate epithelial stem cells: a model of prostatic homeostasis
title_short Proximal location of mouse prostate epithelial stem cells: a model of prostatic homeostasis
title_sort proximal location of mouse prostate epithelial stem cells: a model of prostatic homeostasis
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2173539/
https://www.ncbi.nlm.nih.gov/pubmed/12082083
http://dx.doi.org/10.1083/jcb.200202067
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