Cloning of the first sn1-DAG lipases points to the spatial and temporal regulation of endocannabinoid signaling in the brain

Diacylglycerol (DAG) lipase activity is required for axonal growth during development and for retrograde synaptic signaling at mature synapses. This enzyme synthesizes the endocannabinoid 2-arachidonoyl-glycerol (2-AG), and the CB1 cannabinoid receptor is also required for the above responses. We no...

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Detalles Bibliográficos
Autores principales: Bisogno, Tiziana, Howell, Fiona, Williams, Gareth, Minassi, Alberto, Cascio, Maria Grazia, Ligresti, Alessia, Matias, Isabel, Schiano-Moriello, Aniello, Paul, Praveen, Williams, Emma-Jane, Gangadharan, Uma, Hobbs, Carl, Di Marzo, Vincenzo, Doherty, Patrick
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2003
Materias:
Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2173631/
https://www.ncbi.nlm.nih.gov/pubmed/14610053
http://dx.doi.org/10.1083/jcb.200305129

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