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Proteolytic release of the carboxy-terminal fragment of proHB-EGF causes nuclear export of PLZF
Cleavage of membrane-anchored heparin-binding EGF-like growth factor (proHB-EGF) via metalloprotease activation yields amino- and carboxy-terminal regions (HB-EGF and HB-EGF-C, respectively), with HB-EGF widely recognized as a key element of epidermal growth factor receptor transactivation in G prot...
Autores principales: | Nanba, Daisuke, Mammoto, Akiko, Hashimoto, Koji, Higashiyama, Shigeki |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
The Rockefeller University Press
2003
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2173632/ https://www.ncbi.nlm.nih.gov/pubmed/14597771 http://dx.doi.org/10.1083/jcb.200303017 |
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