Traffic control: p120-catenin acts as a gatekeeper to control the fate of classical cadherins in mammalian cells

Proteins of the p120 family have been implicated in the regulation of cadherin-based cell adhesion, but their relative importance in this process and their mechanism of action have remained less clear. Three papers in this issue suggest that p120 plays a key role in maintaining normal levels of cadh...

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Detalles Bibliográficos
Autores principales: Peifer, Mark, Yap, Alpha S.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2003
Materias:
Comment
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2173635/
https://www.ncbi.nlm.nih.gov/pubmed/14610049
http://dx.doi.org/10.1083/jcb.200310090
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author Peifer, Mark
Yap, Alpha S.
author_facet Peifer, Mark
Yap, Alpha S.
author_sort Peifer, Mark
collection PubMed
description Proteins of the p120 family have been implicated in the regulation of cadherin-based cell adhesion, but their relative importance in this process and their mechanism of action have remained less clear. Three papers in this issue suggest that p120 plays a key role in maintaining normal levels of cadherin in mammalian cells, and that it may do so by regulating cadherin trafficking (Chen et al., 2003; Davis et al., 2003; Xiao et al., 2003).
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spelling pubmed-21736352008-05-01 Traffic control: p120-catenin acts as a gatekeeper to control the fate of classical cadherins in mammalian cells Peifer, Mark Yap, Alpha S. J Cell Biol Comment Proteins of the p120 family have been implicated in the regulation of cadherin-based cell adhesion, but their relative importance in this process and their mechanism of action have remained less clear. Three papers in this issue suggest that p120 plays a key role in maintaining normal levels of cadherin in mammalian cells, and that it may do so by regulating cadherin trafficking (Chen et al., 2003; Davis et al., 2003; Xiao et al., 2003). The Rockefeller University Press 2003-11-10 /pmc/articles/PMC2173635/ /pubmed/14610049 http://dx.doi.org/10.1083/jcb.200310090 Text en Copyright © 2003, The Rockefeller University Press This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Comment
Peifer, Mark
Yap, Alpha S.
Traffic control: p120-catenin acts as a gatekeeper to control the fate of classical cadherins in mammalian cells
title Traffic control: p120-catenin acts as a gatekeeper to control the fate of classical cadherins in mammalian cells
title_full Traffic control: p120-catenin acts as a gatekeeper to control the fate of classical cadherins in mammalian cells
title_fullStr Traffic control: p120-catenin acts as a gatekeeper to control the fate of classical cadherins in mammalian cells
title_full_unstemmed Traffic control: p120-catenin acts as a gatekeeper to control the fate of classical cadherins in mammalian cells
title_short Traffic control: p120-catenin acts as a gatekeeper to control the fate of classical cadherins in mammalian cells
title_sort traffic control: p120-catenin acts as a gatekeeper to control the fate of classical cadherins in mammalian cells
topic Comment
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2173635/
https://www.ncbi.nlm.nih.gov/pubmed/14610049
http://dx.doi.org/10.1083/jcb.200310090
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