Rab27A and its effector MyRIP link secretory granules to F-actin and control their motion towards release sites

The GTPase Rab27A interacts with myosin-VIIa and myosin-Va via MyRIP or melanophilin and mediates melanosome binding to actin. Here we show that Rab27A and MyRIP are associated with secretory granules (SGs) in adrenal chromaffin cells and PC12 cells. Overexpression of Rab27A, GTPase-deficient Rab27A...

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Detalles Bibliográficos
Autores principales: Desnos, Claire, Schonn, Jean-Sébastien, Huet, Sébastien, Tran, Viet Samuel, El-Amraoui, Aziz, Raposo, Graça, Fanget, Isabelle, Chapuis, Catherine, Ménasché, Gaël, de Saint Basile, Geneviève, Petit, Christine, Cribier, Sophie, Henry, Jean-Pierre, Darchen, François
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2003
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2173641/
https://www.ncbi.nlm.nih.gov/pubmed/14610058
http://dx.doi.org/10.1083/jcb.200302157

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