Myosin V motor proteins: marching stepwise towards a mechanism

Mammalian myosin V motors transport cargo processively along actin filaments. Recent biophysical and structural studies have led to a detailed understanding of the mechanism of myosin V, making it perhaps the best understood cytoskeletal motor. In addition to describing the mechanism, this review wi...

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Detalles Bibliográficos
Autor principal: Vale, Ronald D.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2003
Materias:
Mini-Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2173644/
https://www.ncbi.nlm.nih.gov/pubmed/14610051
http://dx.doi.org/10.1083/jcb.200308093
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author Vale, Ronald D.
author_facet Vale, Ronald D.
author_sort Vale, Ronald D.
collection PubMed
description Mammalian myosin V motors transport cargo processively along actin filaments. Recent biophysical and structural studies have led to a detailed understanding of the mechanism of myosin V, making it perhaps the best understood cytoskeletal motor. In addition to describing the mechanism, this review will illustrate how “dynamic” single molecule measurements can synergize with “static” protein structural studies to produce amazingly clear information on the workings of a nanometer-scale machine.
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spelling pubmed-21736442008-05-01 Myosin V motor proteins: marching stepwise towards a mechanism Vale, Ronald D. J Cell Biol Mini-Review Mammalian myosin V motors transport cargo processively along actin filaments. Recent biophysical and structural studies have led to a detailed understanding of the mechanism of myosin V, making it perhaps the best understood cytoskeletal motor. In addition to describing the mechanism, this review will illustrate how “dynamic” single molecule measurements can synergize with “static” protein structural studies to produce amazingly clear information on the workings of a nanometer-scale machine. The Rockefeller University Press 2003-11-10 /pmc/articles/PMC2173644/ /pubmed/14610051 http://dx.doi.org/10.1083/jcb.200308093 Text en Copyright © 2003, The Rockefeller University Press This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Mini-Review
Vale, Ronald D.
Myosin V motor proteins: marching stepwise towards a mechanism
title Myosin V motor proteins: marching stepwise towards a mechanism
title_full Myosin V motor proteins: marching stepwise towards a mechanism
title_fullStr Myosin V motor proteins: marching stepwise towards a mechanism
title_full_unstemmed Myosin V motor proteins: marching stepwise towards a mechanism
title_short Myosin V motor proteins: marching stepwise towards a mechanism
title_sort myosin v motor proteins: marching stepwise towards a mechanism
topic Mini-Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2173644/
https://www.ncbi.nlm.nih.gov/pubmed/14610051
http://dx.doi.org/10.1083/jcb.200308093
work_keys_str_mv AT valeronaldd myosinvmotorproteinsmarchingstepwisetowardsamechanism

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