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A core function for p120-catenin in cadherin turnover

p120-catenin stabilizes epithelial cadherin (E-cadherin) in SW48 cells, but the mechanism has not been established. Here, we show that p120 acts at the cell surface to control cadherin turnover, thereby regulating cadherin levels. p120 knockdown by siRNA expression resulted in dose-dependent elimina...

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Detalles Bibliográficos
Autores principales: Davis, Michael A., Ireton, Renee C., Reynolds, Albert B.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2003
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2173649/
https://www.ncbi.nlm.nih.gov/pubmed/14610055
http://dx.doi.org/10.1083/jcb.200307111
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author Davis, Michael A.
Ireton, Renee C.
Reynolds, Albert B.
author_facet Davis, Michael A.
Ireton, Renee C.
Reynolds, Albert B.
author_sort Davis, Michael A.
collection PubMed
description p120-catenin stabilizes epithelial cadherin (E-cadherin) in SW48 cells, but the mechanism has not been established. Here, we show that p120 acts at the cell surface to control cadherin turnover, thereby regulating cadherin levels. p120 knockdown by siRNA expression resulted in dose-dependent elimination of epithelial, placental, neuronal, and vascular endothelial cadherins, and complete loss of cell–cell adhesion. ARVCF and δ-catenin were functionally redundant, suggesting that proper cadherin-dependent adhesion requires the presence of at least one p120 family member. The data reveal a core function of p120 in cadherin complexes, and strongly predict a dose-dependent loss of E-cadherin in tumors that partially or completely down-regulate p120.
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spelling pubmed-21736492008-05-01 A core function for p120-catenin in cadherin turnover Davis, Michael A. Ireton, Renee C. Reynolds, Albert B. J Cell Biol Article p120-catenin stabilizes epithelial cadherin (E-cadherin) in SW48 cells, but the mechanism has not been established. Here, we show that p120 acts at the cell surface to control cadherin turnover, thereby regulating cadherin levels. p120 knockdown by siRNA expression resulted in dose-dependent elimination of epithelial, placental, neuronal, and vascular endothelial cadherins, and complete loss of cell–cell adhesion. ARVCF and δ-catenin were functionally redundant, suggesting that proper cadherin-dependent adhesion requires the presence of at least one p120 family member. The data reveal a core function of p120 in cadherin complexes, and strongly predict a dose-dependent loss of E-cadherin in tumors that partially or completely down-regulate p120. The Rockefeller University Press 2003-11-10 /pmc/articles/PMC2173649/ /pubmed/14610055 http://dx.doi.org/10.1083/jcb.200307111 Text en Copyright © 2003, The Rockefeller University Press This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Article
Davis, Michael A.
Ireton, Renee C.
Reynolds, Albert B.
A core function for p120-catenin in cadherin turnover
title A core function for p120-catenin in cadherin turnover
title_full A core function for p120-catenin in cadherin turnover
title_fullStr A core function for p120-catenin in cadherin turnover
title_full_unstemmed A core function for p120-catenin in cadherin turnover
title_short A core function for p120-catenin in cadherin turnover
title_sort core function for p120-catenin in cadherin turnover
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2173649/
https://www.ncbi.nlm.nih.gov/pubmed/14610055
http://dx.doi.org/10.1083/jcb.200307111
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