Cup-ling oskar RNA localization and translational control

RNA localization and spatially restricted translational control can serve to deploy specific proteins to particular places within a cell. oskar (osk) RNA is a key initiatior of posterior patterning and germ cell specification in Drosophila, and its localization and translation are under elaborate co...

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Detalles Bibliográficos
Autor principal: Lasko, Paul
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2003
Materias:
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2173710/
https://www.ncbi.nlm.nih.gov/pubmed/14691130
http://dx.doi.org/10.1083/jcb.200311123
Descripción
Sumario:RNA localization and spatially restricted translational control can serve to deploy specific proteins to particular places within a cell. oskar (osk) RNA is a key initiatior of posterior patterning and germ cell specification in Drosophila, and its localization and translation are under elaborate control. In this issue, Wilhelm et al. (2003) show that the protein Cup both promotes osk localization and participates in repressing translation of unlocalized osk.

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