Autocrine laminin-5 ligates α6β4 integrin and activates RAC and NFκB to mediate anchorage-independent survival of mammary tumors

Invasive carcinomas survive and evade apoptosis despite the absence of an exogenous basement membrane. How epithelial tumors acquire anchorage independence for survival remains poorly defined. Epithelial tumors often secrete abundant amounts of the extracellular matrix protein laminin 5 (LM-5) and f...

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Detalles Bibliográficos
Autores principales: Zahir, Nastaran, Lakins, Johnathon N., Russell, Alan, Ming, WenYu, Chatterjee, Chandrima, Rozenberg, Gabriela I., Marinkovich, M. Peter, Weaver, Valerie M.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2003
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2173718/
https://www.ncbi.nlm.nih.gov/pubmed/14691145
http://dx.doi.org/10.1083/jcb.200302023

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2173718/
https://www.ncbi.nlm.nih.gov/pubmed/14691145
http://dx.doi.org/10.1083/jcb.200302023

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